Corticosteroid delivery using oral mucosa equivalents for the treatment of inflammatory mucosal diseases

Oral lichen planus (OLP) is an immune-mediated disease of the oral mucosa with idiopathic aetiology. It frequently treated topical corticosteroids (applied as gels, mouthwashes, or sprays); however, mucosal exposure times are short because removal by constant flow saliva and mechanical forces. In this study we used cell monolayers, well equivalents (OMEs) containing activated T-cells, to examine corticosteroid potency delivery clobetasol-17-propionate from a novel electrospun mucoadhesive patch. The OMEs displayed tight junctions, desmosomes, hemidesmosomes, efficient permeability barrier. Following application cells cultured degree cytotoxicity measured correlated level recognized for each corticosteroid; contrast, were largely unaffected treatment. Permeation into through was time- dose-dependent, regardless whether delivered in liquid form patch, both liquid- patch-delivered significantly reduced secretion interleukin-2 T-cells. This confirms that more suitable models than monolayers evaluating toxicity drug delivery. After exposure, accumulated at higher betamethasone-17-valerate hydrocortisone-17-valerate, exerted its immunosuppressive actions following via patch system, highlighting efficacy mode treat OLP.